Endocrine Therapy

Targeted hormonal treatment as part of personalised cancer care.

At Melna Oncology Centre, we understand that every cancer diagnosis is unique. Some cancers depend on hormones to grow and spread. Endocrine therapy, also known as hormone therapy, is a form of systemic cancer treatment that works by reducing the production of certain hormones or blocking their effects on cancer cells.

Under the care of Dr Thandeka Buthelezi-Zulu, Specialist Radiation and Clinical Oncologist, treatment recommendations are guided by your diagnosis, cancer characteristics, overall health and individual needs.

Endocrine therapy is a cancer treatment that targets the relationship between hormones and certain cancer cells.

Hormones are natural chemical messengers produced by the body. They regulate many important functions, including growth, metabolism and reproduction. However, some cancers use hormones such as oestrogen or testosterone to support their growth.

Endocrine therapy helps slow or stop the growth of hormone-sensitive cancers by reducing hormone levels or preventing hormones from stimulating cancer cells.

Unlike chemotherapy, which primarily targets rapidly dividing cells, endocrine therapy specifically interferes with hormone-related pathways involved in cancer growth.

Endocrine therapy is commonly used to treat certain types of:

Breast Cancer

Some breast cancers have hormone receptors that allow oestrogen or progesterone to influence cancer growth. Endocrine therapy can help reduce the risk of recurrence following initial treatment, manage advanced disease or, in selected cases, be used before surgery.

Prostate Cancer

Many prostate cancers depend on male hormones, particularly testosterone, for growth. Hormonal treatments can reduce testosterone production or block its effects, helping control the disease.

Other Hormone-Sensitive Cancers

Endocrine therapy may also be considered for selected other cancers where hormone-related pathways play a role. Its suitability depends on the specific diagnosis and clinical findings.

The treatment approach depends on the type of cancer and how it responds to hormones.

Endocrine therapy may work by:

• Blocking hormones from attaching to receptors on cancer cells.
• Reducing the body’s production of certain hormones.
• Suppressing hormone production by the ovaries or testes.
• Interfering with hormonal signals that encourage cancer growth.

Treatment may involve oral medication, injections or, in selected circumstances, procedures that reduce hormone production.

Before recommending endocrine therapy, your oncologist will review your diagnosis, medical history, relevant test results and treatment goals.

Depending on your condition, endocrine therapy may be prescribed on its own or combined with other cancer treatments, including surgery, radiotherapy, chemotherapy or targeted therapies.

Some patients receive endocrine therapy for several months, while others may require treatment for several years or longer.

Regular follow-up appointments help your oncology team monitor treatment effectiveness, manage side effects and adjust your care plan where necessary.

As endocrine therapy affects hormone activity, some patients may experience changes related to reduced hormone levels.

Depending on the medication and type of treatment, possible side effects may include:

• Hot flushes or night sweats.
• Fatigue or reduced energy levels.
• Mood changes.
• Joint or muscle discomfort.
• Changes in sexual function or libido.
• Menstrual changes in some patients.
• Changes in bone density over time.

Not every patient experiences these effects, and their severity can vary considerably.

Certain endocrine treatments also carry additional medication-specific risks. Your oncologist will explain the potential benefits, side effects and monitoring requirements associated with your prescribed treatment.

Never stop or change your prescribed cancer medication without first consulting your treating oncology team.

At Melna Oncology Centre, we believe that effective cancer care begins with understanding the individual behind the diagnosis.

Dr Thandeka Buthelezi-Zulu provides specialist oncology consultations and personalised treatment planning, helping patients understand their treatment options and make informed decisions about their care.

Whether endocrine therapy is recommended as a primary treatment or as part of a broader cancer care plan, our focus remains on evidence-based treatment, compassionate support and ongoing patient care.

Is endocrine therapy the same as chemotherapy?

No. Although both are forms of systemic cancer treatment, they work differently. Chemotherapy generally targets rapidly dividing cells, while endocrine therapy interferes with hormones that support the growth of certain cancers.

Is endocrine therapy only used for breast cancer?

No. It is also widely used in prostate cancer treatment and may be appropriate for selected other hormone-sensitive cancers.

How long does endocrine therapy last?

Treatment duration varies according to the cancer type, stage, medication and treatment goals. Some patients require treatment for several years, while others receive it for different periods depending on their clinical circumstances.

Can endocrine therapy be combined with radiotherapy?

Yes. In certain cancers, endocrine therapy and radiotherapy may be used together or at different stages of treatment. Your oncologist will determine the most appropriate treatment sequence.

Will I need regular follow-up appointments?

Yes. Follow-up appointments allow your oncology team to assess your response to treatment, monitor potential side effects and review your ongoing care.

If you have been diagnosed with a hormone-sensitive cancer or would like to understand whether endocrine therapy may be appropriate for you, Melna Oncology Centre is here to help.

Speak to our team about arranging a specialist oncology consultation.

Melna Oncology Centre
Medicare Medical Centre, Suite 12
85 Bird Street, Newcastle, KwaZulu-Natal

Telephone: 034 317 3460
WhatsApp: 063 037 3819
Email:admin@melnaoncology.co.za